| FGF23 ELISA kit , Antibody, Recombinant | |
| A biomarker for osteoporosis and cardiovascular calcification | |
| Order FGF23 Products Please Checkout | |
| FGF23 induces left ventricular hypertrophy | |
| Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 have been linked to greater risks of LVH and mortality in patients with CKD, but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort. FGF23 caused pathological hypertrophy of isolated rat cardiomyocytes via FGF receptor–dependent activation of the calcineurin-NFAT signaling pathway, but this effect was independent of klotho, the coreceptor for FGF23 in the kidney and parathyroid glands. Intramyocardial or intravenous injection of FGF23 in wild-type mice resulted in LVH, and klotho-deficient mice demonstrated elevated FGF23 levels and LVH. In an established animal model of CKD, treatment with an FGF–receptor blocker attenuated LVH, although no change in blood pressure was observed. These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD. | |
| Christian Faul et al. J Clin Invest. 2011, doi:10.1172/JCI46122. | |
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Human FGF23 ELISA |
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Anti Human FGF-23 IgG Code No.: A00147-01-100 Size: 100 ug Price: $260.00 USD Host: Rabbit Antigen: human FGF-23 (25-179). Ab Type: Polyclonal IgG Purification: Protein A Applications: E, IHC, Working Dilution: IHC 2-4 ug/ml) Data Sheet: PDF |
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Human FGF23 C-Terminal Fragment His Tag Rec Code No.: 00147-06-100 Size: 96 T Price: $360.00 USD Protein ID :Q9GZV9 Gene ID : 8074 Tag; His Tag on N-terminus Data Sheet: PDF |
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Human FGF23 N-Terminal Fragment
(25-179) His Tag Rec Code No.: 00147-08-100 Size: 96 T Price: $360.00 USD Protein ID :Q9GZV9 Gene ID : 8074 Tag; His Tag on N-terminus Data Sheet: PDF |
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| Anti Human
FGF23 N-Terminal Antibody Code No.: A00147-01-100 Size: 100 ug Price: $260.00 USD Host: rabbit Antigen: human FGF23 (25-179). Ab Type: Purified IgG Purification: Protein G Applications: E, IHC, WB Working Dilution: 0.1ug/ml) Data Sheet: PDF |
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| Anti Human
FGF23 C-Terminal Monoclonal Antibody Code No.: A00147-06-100 Size: 100 ug Price: $220.00 USD Host: Mouse Antigen: human FGF23 C Terminal Fragment. Ab Type: Purified IgG Purification: Protein G Applications: E Working Dilution: 0.1ug/ml) Data Sheet: PDF |
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| Anti Human
FGF23 C-Terminal Monoclonal Antibody Code No.: A00147-07-100 Size: 100 ug Price: $220.00 USD Host: Mouse Antigen: human FGF23 C Terminal Fragment. Ab Type: Purified IgG Purification: Protein G Applications: E Working Dilution: 0.1ug/ml) Data Sheet: PDF |
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Mouse FGF-15 His Tag Rec Code No.: 00659-03-100 Size: 96 T Price: $360.00 USD Protein ID :O35622 Gene ID : 14170 Tag; His Tag on N-terminus Data Sheet: PDF |
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| Soluble and secreted Klotho ELISA Kit | |
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| More FGF family Proteins |
| Name | Code No. |
Size |
Price ($) |
| FGF-23 (Human) ELISA Kit | 96 T |
460 |
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| FGF-23 (Human) ELISA Kit | 192 T |
840 |
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| FGF-23 (Human) ELISA Kit | 384 T |
1950 |
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| FGF-23 C Terminal (Human)Recombinant | 100 ug |
360.00 |
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| FGF-23 N Terminal (Human)Recombinant | 100 ug |
360.00 |
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| FGF-15 (Mouse) Rec | 100 ug |
360.00 |
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| Anti Human FGF-23 N Terminal Fragment IgG | 100 ug |
260.00 |
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| Anti Human FGF-23 N Terminal Fragment IgG Biotinylated | 50 ug |
290.00 |
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| Anti Human FGF-23 IgG | 100 ug |
260.00 |
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| Anti FGF-23 C Terminal (Human) Monoclonal Antibody | 100 ug |
220.00 |
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| Anti FGF-23 C Terminal (Human) Monoclonal Antibody | 100 ug |
220.00 |
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| Anti FGF-23 C Terminal (Human) Monoclonal Antibody Biotinylated | 50 ug |
290.00 |
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| Anti FGF-23 C Terminal (Human) Monoclonal Antibody Biotinylated | 50 ug |
290.00 |
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