| Vitamin D Binding Protein (VDBP)/Gc Globulin | |
| A biomarker for Organ Injury,CPOD and osteoporosis | |
Alternative name:
|
|
| Gc-Globulin, a multifunctional plasma protein with 55 KD was belongs to albumin superfamily. Gc-Globulin is an hepatokine which is mainly synthesed in hepatocytes and released into circulation. Gc-Globulin can bind extracellular actin released by cell necrosis and tissue injury as actin-scavenging systems. Circulating Gc-Globulin levels are decreased in multi-organ injury or severe injury patients. | |
| Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case-control study | |
| High concentrations of circulating 25-hydroxyvitamin D [25(OH)D] have been associated with elevated pancreatic cancer risk. As this is contrary to an expected inverse association betweenvitamin D status and cancer, we examined whethervitamin D binding protein (DBP), the primary carrier of Vitamin D compounds in circulation, plays a role in this relationship. Prediagnostic serum DBP and 25(OH)D were studied in relation to risk of pancreatic cancer in a nested case-control study of 234 cases and 234 controls in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish men. ORs and 95% CIs were estimated using logistic regression, and statistical tests were two-sided. We found that DBP and 25(OH)D were correlated (r = 0.27, P < 0.0001), and DBP was inversely associated with pancreatic cancer risk (OR = 0.66, 95% CI = 0.39-1.12, for the highest vs. lowest quartile; P(trend) = 0.02). Importantly, this association seemed to have a threshold between quartiles 2 to 4 and quartile 1, and was primarily evident among men with concurrent high 25(OH)D concentrations (OR = 0.33, 95% CI = 0.16-0.70 for highest vs. lowest quartile; P(trend) = 0.002), with no association in men with lower serum 25(OH)D (OR = 1.28, 95% CI = 0.62-2.61 for highest vs. lowest quartile, P(trend) 0.63, P(interaction) = 0.01). Men with higher 25(OH)D concentrations and serum DBP below the median showed greatly elevated risk of pancreatic cancer (OR = 5.01, 95% CI 2.33-10.78, for highest vs. lowest quartile; P(trend) < 0.0001), while risk was weakly inversely associated with serum 25(OH)D when DBP concentrations were higher (P(interaction) = 0.001). Taken together, our findings indicate that higher DBP concentrations may sequester more 25(OH)D and reduce free 25(OH)D bioavailability. Simultaneous examination of DBP and 25(OH)D may be important in determining the association of Vitamin D with cancer risk. | |
| Weinstein SJ et al. Cancer Res.2012 Mar 1;72(5):1190-8. Epub 2012 Jan 9. | |
| Vitamin D stimulates transcription of anti-angiogenic and apoptotic factors that may suppress tumours, whilst vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain if the vitamin D axis is altered in lung cancer or influences prognosis.148 lung cancer patients, 68 other intrathoracic cancer patients and 33 non-cancer controls were studied for up to 5 years. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry.Low serum DBP levels predicted lung cancer specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival, and VDR expression was variable in tumours.Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells further study on its involvement in lung cancer is merited. | |
| Turner A et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7252-6. Epub 2008 May 14. | |
 |
Human
Gc-Globulin/Vitamin D Binding Protein (VDBP) ELISA Kit Code No.: SK00627-01 Size: 96 T Price: $360.00 USD Standard Range: 0.156-10 ng/ml Sensitivity: 39 pg/ml Sample Type: serum, plasma, urine Dilution Factor: 25000 or 50000 Intra-CV: 4-6% Inter-CV: 8-10% Data Sheet: PDF |
|
|
| Name | Code No. |
Size |
Price ($) |
| Gc-Globulin/Vitamin D Binding Protein (VDBP) (Human) ELISA Kit | 96 T |
360.00 |
|
| Gc-Globulin/Vitamin D Binding Protein (VDBP) (Human) Monoclonal Antibody | 100 ug |
260.00 |
|
| Gc-Globulin/Vitamin D Binding Protein (VDBP) (Human) Monoclonal Antibody | 100 ug |
260.00 |
|